It can cause allergic skin rashes in some people. 10-18-2010; View abstract. HIV/AIDS. View abstract. Circulating vitamin K levels in patients with fractures. Treatment of warfarin-induced hair loss with ubidecarenone. Santa-Mara, I., Santpere, G., MacDonald, M. J., Gomez de, Barreda E., Hernandez, F., Moreno, F. J., Ferrer, I., and Avila, J. Coenzyme q induces tau aggregation, tau filaments, and Hirano bodies. Henriksen JE, Andersen CB, Hother-Nielsen O, et al. View abstract. Studies on coenzyme Q and diabetes mellitus. View abstract. Nutr Res 2001;21:551-67. Eriksson JG, Forsen TJ, Mortensen SA, Rohde M. The effect of coenzyme Q10 administration on metabolic control in patients with type 2 diabetes mellitus. XVI. Bentov, Y., Esfandiari, N., Burstein, E., and Casper, R. F. The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients. Possible role of ubiquinone in the treatment of massive hypertriglyceridemia resistant to PUFA and fibrates. View abstract. Biogerontology. View abstract. Diarrhea 5. Nishino, M., Usami, M., Sugimura, S., and Yoshizaki, S. [Case of drug-induced pneumonitis associated with a dietary supplement containing CoQ10]. View abstract. Biofactors 2005;25(1-4):235-240. Gerards, M., van den Bosch, B., Calis, C., Schoonderwoerd, K., van, Engelen K., Tijssen, M., de, Coo R., van der Kooi, A., and Smeets, H. Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy. 2014;2014:798957. A preliminary study. View abstract. J Clin Pharmacol 1990;30:596-608. Nutrients 2018;10(11). Ho MJ, Bellusci A, Wright JM. Effect of a nutritional supplement containing vitamin E, selenium, vitamin c and coenzyme Q10 on serum PSA in patients with hormonally untreated carcinoma of the prostate: a randomised placebo-controlled study. 2017 Apr;86(4):560-66. Cochrane Database Syst.Rev. Lipid-lowering drugs and mitochondrial function: Effects of HMG-CoA Reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Exercise capacity and idebenone intervention in children and adolescents with Friedreich ataxia. Judy WV, Willis RA, and Folkers K. Regression of prostate cancer and plasma specific antigens (PSA) in patients on treatment with COQ10. pregnancy, upcoming surgery, etc. Exp.Gerontol. View abstract. Although not all side effects are known, ubiquinone (the active ingredient contained in Coenzyme Q10) is thought to be likely safe for most adults when used as directed. Shilov, A. M., Mel'nik, M. V., Voevodina, E. S., Osiia, A. O., and Griaznov, D. A. J Neurol.Sci 4-15-2008;267(1-2):174-176. View abstract. View abstract. J Cardiothorac.Vasc.Anesth. Brain 2013;136(Pt 2):e230. These severe side effects may intimate that you should stop taking the supplements. View abstract. Role of metabolic therapy in cardiovascular disease. View abstract. View abstract. The exact mechanism underlying CoQ10‑mediated protection against osteoporosis remains to be elucidated. 2006;21(3):253-255. Palomaki, A., Malminiemi, K., Solakivi, T., and Malminiemi, O. Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo. J Support Oncol. Eur J Drug Metab Pharmacokinet 2002;27:185-92. View abstract. Ann.Intern.Med 11-7-2000;133(9):745-746. Gutzmann, H., Kuhl, K. P., Hadler, D., and Rapp, M. A. View abstract. Progression despite replacement of a myopathic form of coenzyme Q10 defect. Chan A, Reichmann H, Kogel A, et al. Early research shows that taking coenzyme Q10 by mouth might protect the heart in children aged 3-12 years who are being treated with a class of drugs called anthracyclines. Reported side effects from the use of Coenzyme-Q10 include the following: High levels of liver enzymes. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. One large research study shows that taking coenzyme Q10 in large doses (2.4 grams daily) for up to 5 years does not stop Huntington disease symptoms from getting worse. Coenzyme q10 side effects are often mild. Farsi F, Heshmati J, Keshtkar A, et al. 2015 Jun;35(3):338-40. doi: 10.1097/JCP.0000000000000326. View abstract. Ylikoski, T., Piirainen, J., Hanninen, O., and Penttinen, J. Proc.Natl.Acad.Sci U.S.A 1971;68(10):2332-2335. Shao L, Ma A, Figtree G, Zhang P. Combination therapy with coenzyme Q10 and trimetazidine in patients with acute viral myocarditis. 1996;11(5):549-554. Koroshetz WJ. 2012;25(2):261-270. View abstract. Rodriguez-Hernandez, A., Cordero, M. D., Salviati, L., Artuch, R., Pineda, M., Briones, P., Gomez, Izquierdo L., Cotan, D., Navas, P., and Sanchez-Alcazar, J. Mol Aspects Med 1994;15:187-93. Soongswang J, Sangtawesin C, Durongpisitkul K, et al. Tomasetti, M., Alleva, R., Solenghi, M. D., and Littarru, G. P. Distribution of antioxidants among blood components and lipoproteins: significance of lipids/CoQ10 ratio as a possible marker of increased risk for atherosclerosis. View abstract. Lerman-Sagie T, Rustin P, Lev D, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cochrane Database Syst Rev. Is Coenzyme Q10 Safe? 2017 Jul 24;17(1):196. Current opinions in headache pathogenesis: introduction and synthesis. Besides aging and genetic defects, There are also some factors that contribute to CoQ10 deficiency; including —, However, the human body is capable to create Coenzyme Q10, but it doesn’t always do so consistently. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Lee YJ, Cho WJ, Kim JK, Lee DC. View abstract. Bergamin, C. S., Rolim, L. C., Dib, S. A., and Moises, R. S. Unusual occurrence of intestinal pseudo obstruction in a patient with maternally inherited diabetes and deafness (MIDD) and favorable outcome with coenzyme Q10. Because CoQ10 has important functions in the … Di Pierro F, Rossi A, Consensi A, Giacomelli C, Bazzichi L. Role for a water-soluble form of CoQ10 in female subjects affected by fibromyalgia. Int J Sport Nutr 1997;7:197-206. View abstract. Chew, G. T., Watts, G. F., Davis, T. M., Stuckey, B. G., Beilin, L. J., Thompson, P. L., Burke, V., and Currie, P. J. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2 diabetic subjects with left ventricular diastolic dysfunction. Boles RG, Lovett-Barr MR, Preston A, et al. View abstract. View abstract. View abstract. View abstract. CoQ10 levels start to decrease in your body as you age. Zhonghua Nan.Ke.Xue. However, be sure to take this supplement under your doctor’s supervision. View abstract. 2015 Jun;63(5):735-9. doi: 10.1097/JIM.0000000000000202. High blood pressure. Drugs Exp Clin Res 1993;19:65-8.. View abstract. View abstract. View abstract. People take CoQ-10 for a number of health conditions including heart disease and diabetes. This information may not fit your specific health circumstances. Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke. View abstract. FDA. Eur Heart J 2005;26(21):2238-2244. Call your doctor for medical advice about side effects. 2006;(1):CD004426. Early research shows that taking a specific form of coenzyme Q10 called ubiquinol improves autism symptoms in autism patients aged 3-6 years according to parent assessment. View abstract. Adv.Ther 2011;28(12):1105-1113. Br Dent J 1995;178:209-13. View abstract. Liu, Z. X. and Artmann, C. Relative bioavailability comparison of different coenzyme Q10 formulations with a novel delivery system. Cardiol.Young. The impact of coenzyme Q10 on systolic function in patients with chronic heart failure. A lung disease that makes it harder to breathe (chronic obstructive pulmonary disease or COPD). View abstract. View abstract. View abstract. 5. [Trusted Source 16]. Gvozdjáková A, Kucharská J, Ostatníková D, et al. Greenberg S, Frishman WH. [Trusted Source 4]. View abstract. Goda, S., Hamada, T., Ishimoto, S., Kobayashi, T., Goto, I., and Kuroiwa, Y. View abstract. View abstract. Sander S, Coleman CI, Patel AA, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. 2006 Mar-Apr;12(2):26-31; quiz 32-3. J Cardiothorac.Vasc.Anesth. 2009;13(3):303-308. In: Folkers K and Yamura Y. Biomedical and Clinical Aspects of Coenzyme Q. Amsterdam: Elsevier Science Publications;1984. View abstract. Alahmar AT. [Prophylaxis of ischemic heart lesions during chronic heart failure with complex therapy using Q10 coenzyme]. A. Ubiquinol/ubiquinone ratio as marker of oxidative stress in coronary artery disease. Strijks, E., Kremer, H. P., and Horstink, M. W. Q10 therapy in patients with idiopathic Parkinson's disease. Taking coenzyme Q10 by mouth daily appears to lower systolic blood pressure (the top number) in some people with high systolic blood pressure but normal diastolic blood pressure (the bottom number). View abstract. Clinical analysis of Sodium phosphocreatine on cardiac toxicity induced by anthracycline antibiotics in acute leukemia children [Unknown original title in Chinese]. 2007;61(1):50-60. Be sure to have your blood checked regularly. Effect of an antioxidant-rich multivitamin supplement in cystic fibrosis. Li Z, Wang P, Yu Z, Cong Y, Sun H, Zhang J, et al. Klin.Med (Mosk) 2011;89(4):34-36. Altern.Ther Health Med. Tyler's Herbs of Choice: The Therapeutic Use of Phytomedicinals. 2008;9(13):2327-2337. Cephalalgia 2011;31(8):897-905. View abstract. Eur.J Med.Res 11-12-2003;8(11):485-491. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. 2015 Jan;90(1):24-34. doi: 10.1016/j.mayocp.2014.08.021. Cortes, E. P., Gupta, M., Chou, C., Amin, V. C., and Folkers, K. Adriamycin cardiotoxicity: early detection by systolic time interval and possible prevention by coenzyme Q10. Mild side effects such as insomnia or digestive upsets may occur. View abstract. 2011;(6):CD003917. Strong, M. J. and Pattee, G. L. Creatine and coenzyme Q10 in the treatment of ALS. Zeppilli P, Merlino B De Luca A Palmieri V Santini C Vannicelli R La Rosa Gangi M Cacese R Cameli S Servidei S Ricci E Silvestri G Lippa S Oradei A Littarru GP. View abstract. Coenzyme Q10 and exercise training in chronic heart failure. Eur Urol 2005;47(4):433-439. View abstract. Light sensitivity 11. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. View abstract. View abstract. View abstract. View abstract. View abstract. View abstract. [Trusted Source 1], CoQ10 deficiency is also believed to be associated with conditions such as heart disease, diabetes, cancer, fibromyalgia, declining cognition and muscle conditions. Chen FL, Chang PS, Lin YC, Lin PT. Silver, M. A., Langsjoen, P. H., Szabo, S., Patil, H., and Zelinger, A. View abstract. Ann Otol.Rhinol.Laryngol. 1986;125(3):28S-33S. View abstract. View abstract. View abstract. View abstract. (Torino) 1999;40(3):355-361. Neurotherapeutics. 2009;66(9):1099-1104. Biomed.Chromatogr. Coenzyme Q10 has been found to prevent lipid peroxidation, which occurs when the cell membranes and LDL are exposed to oxidizing conditions that enter from outside the body. A case of mitochondrial encephalomyopathy associated with a muscle coenzyme Q10 deficiency. View abstract. London: Taylor and Francis;1990. https://www.fda.gov/orphan/DESIGNAT/list.htm (Accessed 19 June 2004). Although, CoQ10 plays a vital role in the human body, most healthy individuals have enough CoQ10 naturally. View abstract. Feher, J., Kovacs, B., Kovacs, I., Schveoller, M., Papale, A., and Balacco, Gabrieli C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. View abstract. View abstract. Int J Impot.Res 2010;22(5):298-309. Rodriguez, M. C., MacDonald, J. R., Mahoney, D. J., Parise, G., Beal, M. F., and Tarnopolsky, M. A. 2006;12:464-72. Bioenergetics in clinical medicine. View abstract. Int J Vitam.Nutr Res 1998;68(2):109-113. View abstract. Munkholm H., Hansen H. H., Rasmussen K. Coenzyme Q10 treatment in serious heart failure. View abstract. Sahebkar A, Simental-Mendía LE, Stefanutti C, Pirro M. Supplementation with coenzyme Q10 reduces plasma lipoprotein(a) concentrations but not other lipid indices: A systematic review and meta-analysis. Fumagalli, S., Fattirolli, F., Guarducci, L., Cellai, T., Baldasseroni, S., Tarantini, F., Di, Bari M., Masotti, G., and Marchionni, N. Coenzyme Q10 terclatrate and creatine in chronic heart failure: a randomized, placebo-controlled, double-blind study. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S. Effects of the reduced form of coenzyme Q10 (ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. Early Hum.Dev. Efficacy of eyedrops containing cross-linked hyaluronic acid and coenzyme Q10 in treating patients with mild to moderate dry eye. Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. View abstract. View abstract. Hanioka T, Tanaka M, Ojima M, et al. View abstract. Amsterdam: Elsevier;1985. The effect of pravastatin and atorvastatin on coenzyme Q10. 2016 Jul 1;11(7):e0157541. Mol Aspects Med 1997;18 Suppl:S145-51. Arch Iran Med. Desnuelle, C., Pellissier, J. F., Serratrice, G., Pouget, J., and Turnbull, D. M. [Kearns-Sayre syndrome: mitochondrial encephalomyopathy caused by deficiency of the respiratory chain]. Int J Clin Pharmacol Ther 1998;36:506-9. Am J Hum Genet. Slater, S. K., Nelson, T. D., Kabbouche, M. A., Lecates, S. L., Horn, P., Segers, A., Manning, P., Powers, S. W., and Hershey, A. D. A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Autism. 2009;27(9):1863-1872. Suksomboon N, Poolsup N, Juanak N. Effects of coenzyme Q10 supplementation on metabolic profile in diabetes: a systematic review and meta-analysis. Orlando P, Silvestri S, Galeazzi R, et al. J Am Coll Cardiol 1999;33:1549-52. View abstract. Digiesi V, Cantini F, Oradei A, et al. Folkers, K., Drzewoski, J., Richardson, P. C., Ellis, J., Shizukuishi, S., and Baker, L. Bioenergetics in clinical medicine. J Int Med Res 2002;30:195-9. Medications for cancer (Chemotherapy) interacts with COENZYME Q10. Effects of coenzyme athletic performance system as an ergogenic aid on endurance performance to exhaustion. Pain in the upper part of the abdomen. View abstract. View abstract. Mov Disord. Stacpoole, P. W., DeGrauw, T. J., Feigenbaum, A. S., Hoppel, C., Kerr, D. S., McCandless, S. E., Miles, M. V., Robinson, B. H., and Tang, P. H. Design and implementation of the first randomized controlled trial of coenzyme CoQ(1)(0) in children with primary mitochondrial diseases. 7-1-2008;47(1):27-30. But it is too soon to know if the interaction occurs. Suzuki, H., Naitoh, T., Kuniyoshi, S., Banba, N., Kuroda, H., Suzuki, Y., Hiraiwa, M., Yamazaki, N., Ishikawa, M., Hashigami, Y., and . Eye Contact Lens. 2009;85(10):647-651. CoQ10 can also lower blood sugar levels, so people with diabetes need to monitor their blood sugar levels more closely while taking it or avoid the supplement altogether. View abstract. Co-enzyme Q10: a new drug for cardiovascular disease. Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. View abstract. Witte, K. K., Nikitin, N. P., Parker, A. C., von Haehling, S., Volk, H. D., Anker, S. D., Clark, A. L., and Cleland, J. G. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. In Huntington disease ) Q10 are skin rashes, nausea coenzyme q10 side effects vomiting, irritability increased..., Z. X. and Artmann, C., and Penttinen, J ataxia ) sublingual. Of depression in people with low coenzyme Q10 on myocardial protection during cardiac replacement... In immunomodulation Q10 concentrations in patients with congestive heart failure high intensity training on physical performance athletes... Year of trying to conceive ( infertility ), Fenton S, Folkers K. Partial and regression! 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